Вивчення стабільності уотсон-криківських пар основ нуклеїнових кислот у воді та диметилсульфоксиді: комп'ютерне моделювання методом Монте-Карло
DOI:
https://doi.org/10.7124/bc.000466Анотація
Проведено екстенсивне комп'ютерне моделювання основ нуклеїнових кислот і уотсон-криківських пар у воді та ДМСО методом Монте-Карло. Виявлено, що енергетична невигідність утворення пар у воді зумовлена значним дестабілізуючим внеском розчинника в ентальпію утворення комплексів. Показано, що у ДМСО утворення копланарних пар вигідно. Цей розчинник стабілізує пари A-U і А-Т, а незначна дестабілізація цим розчинником пари G-C значно менша, ніж стабілізація, пов'язана з притягненням між основами.Посилання
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