Вплив гетерогенності системи соматичних клітин ссавців на прояв мутагенезу, індукованого трансформуючими генами аденовірусу
DOI:
https://doi.org/10.7124/bc.000452Анотація
На підставі аналізу літературних та власних даних запропоновано математичну модель прояву індукованого мутагенезу, яка враховує клітинну гетерогенність по періоду генерації в системі онкогенний аденовірус – соматична клітина ссавців. Досліджено вплив деяких параметрів, використаних для побудови математичної моделі, на динаміку мутагенезу. Результати теоретичних розрахунків порівнюються з експериментальними даними.Посилання
Skekhan F, Fridman CJ Malignant transformation: correlation methods in vivo and in vitro. Transformed cell. Eds IL Cameron, TB Pools. Kiev: Naukova Dumka, 1985: 12-70.
Moyer M, Moyer R. virus-induced transformation. Transformed cell. Eds IL Cameron, TB Pools. Kiev: Naukova Dumka, 1985: 176-220.
Magun BE, Gerner YuU. The regulation of the cell cycle in normal and transformed cells. Transformed cell. Eds IL Cameron, TB Pools. Kiev: Naukova Dumka, 1985; 134-157.
Shay J Techniques in Somatic Cell Genetics. 1982 New York: Plenum Press. 541
Luria SE, Delbr?ck M. Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics. 1943;28(6):491-511.
Shkolnik EM. Dynamic models of the cell cycle: Coll. scientific. tr. "The dynamics of chemical and biological systems". Novosibirsk: Nauka, 1989: 230-260.
Howard A, Pelc SR. Synthesis of DNA in normal and irradiated cells and its relationship to chromosome breakage. Heredity. 1952; 6: 261-73.
Zhestyannikov VD DNA repair and its biological significance. Leningrad: Nauka, 1979. 286 p.
Tomilin YaV. The genetic stability of cells. Leningrad: Nauka. 1983. 156 p.
Pardee AB. A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci U S A. 1974;71(4):1286-90.
Dubrow R, Riddle VG, Pardee AB. Different responses to drugs and serum of cells transformed by various means. Cancer Res. 1979;39(7 Pt 1):2718-26.
Fujinaga K, Sawada Y, Uemizu Y, Yamashita T, Shimojo H, Shiroki K, Sugisaki H, Sugimoto K, Takanami M. Nucleotide sequences, integration, and transcription of the adenovirus-12 transforming genes. Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:519-32.
Bos JL, Jochemsen AG, Bernards R, Schrier PI, van Ormondt H, van der Eb AJ. Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation. Virology. 1983;129(2):393-400.
Ariga H. Replication of cloned DNA containing the Alu family sequence during cell extract-promoting simian virus 40 DNA synthesis. Mol Cell Biol. 1984;4(8):1476-82.
Chow KC, Pearson GD. Adenovirus infection elevates levels of cellular topoisomerase I. Proc Natl Acad Sci U S A. 1985;82(8):2247-51.
Zasukhina GD. Cell repair mechanisms and environmental problems. M.: Nauka, 1979. 184 p.
Lukash LL, Buzhievskaya TI, Varshaver NB, Shapiro NI. Oncogenic adenovirus as mutagen for chinese hamster cells in vitro. Somatic Cell Genet. 1981;7(2):133-46.
Shapiro NI, Marshak MI, Varshaver NB. Mutagenic effects of DNA-containing oncogenic viruses and malignant transformation of mammalian cells. Cancer Genet Cytogenet. 1984;13(2):167-79.
Lukash LL, Varshaver NB, Buzhiyevskaya TI, Shapiro NI. The oncogene of BAV-3 as a mutagen. J Cell Sci. 1985;78:97-103.
Lukash LL. [Mutation process and malignant transformation induced by adenoviruses in mammalian cells]. Tsitol Genet. 1986;20(1):55-8, 72.
Lukash LL. Mutagenesis and malignant transformation with oncogenic adenovirus. Mutagenic effects of natural and synthetic polynucleotides. Ed. VV. Morgun. Kiev: Naukova dumka, 1990: 76-93.
Lukash LL, Buzhievskaya TI. Role of early viral genes in mutagenesis. Biotechnology (PA 17604, USA). Lancaster: Curr. progr. techn. Co., 1991. V. 1: 119-31.
Theile M, Scherneck S, Geissler E. Mutagenesis by simian virus 40. I. detection of mutations in Chinese hamster cell lines using different resistance markers. Mutat Res. 1976;37(1):111-23.
Goldberg S, Defendi V. Increased mutation rates in doubly viral transformed Chinese hamster cells. Somatic Cell Genet. 1979;5(6):887-95.
Bellett AJ, Younghusband HB. Spontaneous, mutagen-induced and adenovirus-induced anchorage independent tumorigenic variants of mouse cells. J Cell Physiol. 1979;101(1):33-47.
Marengo C, Mbikay M, Weber J, Thirion JP. Adenovirus-induced mutations at the hypoxanthine phosphoribosyltransferase locus of Chinese hamster cells. J Virol. 1981;38(1):184-90.
Paraskeva C, Roberts C, Biggs P, Gallimore PH. Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned rat liver epithelial cells. J Virol. 1983;46(1):131-6.
Schlehofer JR, Hausen JZ. Induction of mutations within the host cell genome by partially inactivated herpes simplex virus type 1. Virology. 1982;122(2):471-5.
Rubashevskiĭ EL, Lukash LL, Buzhievskaia TI, Landau SM, Sasina LK. [Mutagenicity of the DNA of the herpes simplex virus and of plasmid pBR325tk in cultured mammalian cells]. Dokl Akad Nauk SSSR. 1984;279(3):752-4.
Pilon L, Royal A, Langelier Y. Increased mutation frequency after herpes simplex virus type 2 infection in non-permissive XC cells. J Gen Virol. 1985;66 ( Pt 2):259-65.
Pilon L, Langelier Y, Royal A. Herpes simplex virus type 2 mutagenesis: characterization of mutants induced at the hprt locus of nonpermissive XC cells. Mol Cell Biol. 1986;6(8):2977-83.
Ageenko AI. Oncogenes and carcinogenesis. M.: Meditsina, 1986. 256 p.
Kurokawa T, Igarashi K, Sugino Y. Biochemical studies on bovine adenovirus type 3. III. Cleavage maps of viral DNA by restriction endoncleases EcoRI, BamHI, and HindIII. J Virol. 1978;28(1):212-8.
Igarashi K, Sasada R, Kurokawa T, Niiyama Y, Tsukamoto K, Sugino Y. Biochemical studies on bovine adenovirus type 3. IV. Transformation by viral DNA and DNA fragments. J Virol. 1978;28(1):219-26.
Zalmanzon ES, Vinkele RA, Grigoryeva LV, Turetskaya RL. A study of rat embryo cells transformed in vitro by the bovine adenovirus type 3 (BAV-3) DNA before and after a passage in the host. Virology. 1982;123(2):420-35.
Lukash SI, Lukash LL, Zadoroznyi VF. Mathematical model of mutagenesis dynamics under the action of adenovirus DNA fragment. Biopolym Cell. 1996; 12(3):7-16.
Stabel S, Doerfler W, Friis RR. Integration sites of adenovirus type 12 DNA in transformed hamster cells and hamster tumor cells. J Virol. 1980;36(1):22-40.
Eick D, Stabel S, Doerfler W. Revertants of adenovirus type 12-transformed hamster cell line T637 as tools in the analysis of integration patterns. J Virol. 1980;36(1):41-9.
Botchan M, Stringer J, Mitchison T, Sambrook J. Integration and excision of SV40 DNA from the chromosome of a transformed cell. Cell. 1980;20(1):143-52.
Della Valle G, Fenton RG, Basilico C. Polyoma large T antigen regulates the integration of viral DNA sequences into the genome of transformed cells. Cell. 1981;23(2):347-55.
Hiscott JB, Murphy D, Defendi V. Instability of integrated viral DNA in mouse cells transformed by simian virus 40. Proc Natl Acad Sci U S A. 1981;78(3):1736-40.
Sager R, Anisowicz A, Howell N. Genomic rearrangements in a mouse cell line containing integrated SV40 DNA. Cell. 1981;23(1):41-50.
Stringer JR. DNA sequence homology and chromosomal deletion at a site of SV40 DNA integration. Nature. 1982;296(5855):363-6.
Kuhlmann I, Doerfler W. Loss of viral genomes from hamster tumor cells and nonrandom alterations in patterns of methylation of integrated adenovirus type 12 DNA. J Virol. 1983;47(3):631-6.
Schulz M, Doerfler W. Deletion of cellular DNA at site of viral DNA insertion in the adenovirus type 12-induced mouse tumor CBA-12-1-T. Nucleic Acids Res. 1984;12(12):4959-76.
Lukash LL, Kononenko LI, Buzhievskaia TI, Bykorez AI, Shapiro NI. [Malignant transformation of mouse cultured cells using bovine adenovirus type 3 and modification of this process by MNNG]. Eksp Onkol. 1984;6(5):33-5.
Lukash LL, Shvachko LP, Kostetskaya KV. Mobile genetic elements in mutagenic process, recombination and malignization of human cells. Biopolym Cell. 1996; 12(2):7-19.
Perucho M, Hanahan D, Wigler M. Genetic and physical linkage of exogenous sequences in transformed cells. Cell. 1980;22(1 Pt 1):309-17.
Shapiro NI, Khalizev AE, Luss EV, Manuilova ES, Petrova ON, Varshaver NB. Mutagenesis in cultured mammalian cells. II. Induction of gene mutations in Chinese hamster cells. Mutat Res. 1972;16(7):89-101.
