Молекулярно-генетичні механізми нейроонтогенезу
DOI:
https://doi.org/10.7124/bc.0006D6Ключові слова:
нейрональна індукція, сигнальна трансдукція, генетична експресія, гомеодоменні фактори транскрипції, диференціація і детермінація, фактори росту, нейрогенна стовбурова клітина.Анотація
На грунті літературних даних представлено сучасні уявлення щодо молекулярно-генетичних механізмів нейроонтогенетичних процесів, запропоновано схематичне трактування поступової диференціації нейрональної клітини у ході ускладнення топології міжнейронних зв'язків, а також наведено відомості стосовно онтогенетичної ролі нейрональних стовбурових прогеніторів та розглянуто можливість вивчення топологічних перебудов нейрональних ансамблів під час генерування енграм пам'яті з точки зору мікроембріональних процесів.Посилання
Singer M, Berg P. Genes and Genome A changing perspective. University science book 1991; 929 p.
Bertrand N, Castro DS, Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci. 2002;3(7):517-30.
Mu?oz-Sanju?n I, Brivanlou AH. Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci. 2002;3(4):271-80.
Sasai Y. Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. Neuron. 1998;21(3):455-8.
G?mez-Skarmeta JL, Campuzano S, Modolell J. Half a century of neural prepatterning: the story of a few bristles and many genes. Nat Rev Neurosci. 2003;4(7):587-98.
Li W, LoTurco JJ. Noggin is a negative regulator of neuronal differentiation in developing neocortex. Dev Neurosci. 2000;22(1-2):68-73.
Lumsden A, Krumlauf R. Patterning the vertebrate neuraxis. Science. 1996;274(5290):1109-15.
Tanabe Y, Jessell TM. Diversity and pattern in the developing spinal cord. Science. 1996;274(5290):1115-23.
Goodrich LV, Scott MP. Hedgehog and patched in neural development and disease. Neuron. 1998;21(6):1243-57.
Ruiz i Altaba A, Palma V, Dahmane N. Hedgehog-Gli signalling and the growth of the brain. Nat Rev Neurosci. 2002;3(1):24-33.
Zeng X, Goetz JA, Suber LM, Scott WJ Jr, Schreiner CM, Robbins DJ. A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature. 2001;411(6838):716-20.
Ram?rez-Weber FA, Kornberg TB. Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs. Cell. 1999;97(5):599-607.
Bellaiche Y, The I, Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature. 1998;394(6688):85-8.
Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, Dickson BJ, Basler K. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell. 1999;99(7):803-15.
Liu F, Massagu? J, Ruiz i Altaba A. Carboxy-terminally truncated Gli3 proteins associate with Smads. Nat Genet. 1998;20(4):325-6.
Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science. 1999;284(5415):770-6.
Baron M. An overview of the Notch signalling pathway. Semin Cell Dev Biol. 2003;14(2):113-9.
Maden M. Retinoid signalling in the development of the central nervous system. Nat Rev Neurosci. 2002;3(11):843-53.
Cordes SP. Molecular genetics of cranial nerve development in mouse. Nat Rev Neurosci. 2001;2(9):611-23.
Wang VY, Zoghbi HY. Genetic regulation of cerebellar development. Nat Rev Neurosci. 2001;2(7):484-91.
Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 2001;411(6835):321-5.
Fuchs E, Merrill BJ, Jamora C, DasGupta R. At the roots of a never-ending cycle. Dev Cell. 2001;1(1):13-25.
Miller JR, Moon RT. Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev. 1996;10(20):2527-39.
Xuan S, Baptista CA, Balas G, Tao W, Soares VC, Lai E. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron. 1995;14(6):1141-52.
Gotz M, Wizenmann A, Reinhardt S, Lumsden A, Price J. Selective adhesion of cells from different telencephalic regions. Neuron. 1996;16(3):551-64.
Rallu M, Corbin JG, Fishell G. Parsing the prosencephalon. Nat Rev Neurosci. 2002;3(12):943-51.
Eisen JS. Patterning motoneurons in the vertebrate nervous system. Trends Neurosci. 1999;22(7):321-6.
Benson DL, Colman DR, Huntley GW. Molecules, maps and synapse specificity. Nat Rev Neurosci. 2001;2(12):899-909.
Piccolo S, Agius E, Lu B, Goodman S, Dale L, De Robertis EM. Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell. 1997;91(3):407-16.
Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science. 1996;274(5290):1123-33.
Wilkinson DG. Multiple roles of EPH receptors and ephrins in neural development. Nat Rev Neurosci. 2001;2(3):155-64.
Maina F, Klein R. Hepatocyte growth factor, a versatile signal for developing neurons. Nat Neurosci. 1999;2(3):213-7.
Hu S, Reichardt LF. From membrane to cytoskeleton: enabling a connection. Neuron. 1999;22(3):419-22.
Lanier LM, Gates MA, Witke W, Menzies AS, Wehman AM, Macklis JD, Kwiatkowski D, Soriano P, Gertler FB. Mena is required for neurulation and commissure formation. Neuron. 1999;22(2):313-25.
Alvarez-Buylla A, Garc?a-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci. 2001;2(4):287-93.
Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell. 1999;96(6):795-806.
Kidd T, Bland KS, Goodman CS. Slit is the midline repellent for the robo receptor in Drosophila. Cell. 1999;96(6):785-94.
Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell. 1999;96(6):807-18.
Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, Sotelo C, Ch?dotal A. Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron. 1999;22(3):463-73.
Stein E, Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science. 2001;291(5510):1928-38.
Donoghue MJ, Rakic P. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. J Neurosci. 1999;19(14):5967-79.
Isshiki T, Pearson B, Holbrook S, Doe CQ. Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell. 2001;106(4):511-21.
Qian X, Shen Q, Goderie SK, He W, Capela A, Davis AA, Temple S. Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron. 2000;28(1):69-80.
Burrows RC, Wancio D, Levitt P, Lillien L. Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex. Neuron. 1997;19(2):251-67.
Mehler MF, Mabie PC, Zhu G, Gokhan S, Kessler JA. Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate. Dev Neurosci. 2000;22(1-2):74-85.
Contractor A, Rogers C, Maron C, Henkemeyer M, Swanson GT, Heinemann SF. Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Science. 2002;296(5574):1864-9.
Gerlai R. Eph receptors and neural plasticity. Nat Rev Neurosci. 2001;2(3):205-9.
Lauri SE, Kaukinen S, Kinnunen T, Ylinen A, Imai S, Kaila K, Taira T, Rauvala H. Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. J Neurosci. 1999;19(4):1226-35.
Sanes JR, Lichtman JW. Can molecules explain long-term potentiation? Nat Neurosci. 1999;2(7):597-604.
Bozon B, Davis S, Laroche S. Regulated transcription of the immediate-early gene Zif268: mechanisms and gene dosage-dependent function in synaptic plasticity and memory formation. Hippocampus. 2002;12(5):570-7.
