Biological mutagenes and their role in the natural mutation process
DOI:
https://doi.org/10.7124/bc.0003F7Abstract
Two sets of lethal mutations in chromosome 2 of Drosophila melanogaster have been tested for allelism: lethals induced by viruses and exogenous DNA and those found in different natural populations or arising de novo in the progeny of wild-type flies. It was concluded that the mutagenic effect of different viruses and other sources of DNA, exogenous for the host cells, is to induce single-locus and multiple mutations, which can spread throughout natural populations. Certain population-genetical consequences of the data obtained are discussed, and in particular, the position that during virus-induced mutagenesis, similar multiple chromosome lesions can occur repeatedly and independently in isolated populations of flies a result of a single mutation event.References
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