Synthesis of arginine-containing oligonucleotide-(5'→N)-peptides

Authors

  • V. F. Zarytova Institute of Bioorganic Chemistry, Siberian Branch of the Academy of Sciences of the USSR Novosibirsk, USSR Author
  • E. M. Ivanova Institute of Bioorganic Chemistry, Siberian Branch of the Academy of Sciences of the USSR Novosibirsk, USSR Author
  • S. N. Yarmolyuk Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR Kiev, USSR Author
  • I. V. Alekseeva Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR Kiev, USSR Author

DOI:

https://doi.org/10.7124/bc.00022E

Abstract

A new method for synthesis of oligonucleotide-peptides of phosphoamide type with the use of a mixture of triphenylphosphine, dipyridyldisulphide and N-methylimidazole is suggested. This approach was applied for synthesizing and isolating d(CCCC)-5'-P-Pro-Arg-Val-OMe.

References

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Published

1988-07-20

Issue

Section

Short Communications