In vitro specific cleavage of HIV-1 tat-RNA by catalytically active polyribonucleotide, ribozyme

Authors

  • L. N. Buryanovsky Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author
  • A. D. Schved Institute of Molecular Biology and Genetics, NAS of Ukraine 150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680 Author

DOI:

https://doi.org/10.7124/bc.00041B

Abstract

The hammerhead type ribozyme-mediated cleavage of tat-RNA of human immunodeficiency virus type 1 data are presented. The ribozyme activity was appeared in magnesium-dependent manner at moderate temperature in the presence of monovalent cations and/or potyamines.

References

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Published

1996-03-20

Issue

Section

Structure and Function of Biopolymers