Methyltransferases of plants

Authors

  • E. N. Tishchenko Institute of Plant Physiology and Genetics, NAS of Ukraine 31/17, Vasylkivska, Kyiv, Ukraine, 03022 Author
  • O. V. Dubrovnaya Institute of Plant Physiology and Genetics, NAS of Ukraine 31/17, Vasylkivska, Kyiv, Ukraine, 03022 Author

DOI:

https://doi.org/10.7124/bc.00070C

Keywords:

methylation, cytosine, methyltransferase

Abstract

In the review the current data on the plant cytosine-C5-DNA-methyltransferases (methyltransferase) are summarized. Three different classes of these enzymes – Dnmt1/MET1, Dnmt3 and CMT are discribed. The proposed function, dealing with maintenance and de novo methylation of cytosine residues in symmetric and asymmetric motifs of DNA, is under discussion.

References

Finnegan EJ, Genger RK, Peacock WJ, Dennis ES. DNA METHYLATION IN PLANTS. Annu Rev Plant Physiol Plant Mol Biol. 1998;49:223-247.

Ng HH, Bird A. DNA methylation and chromatin modification. Curr Opin Genet Dev. 1999;9(2):158-63.

Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet. 2000;9(16):2395-402.

Finnegan EJ, Kovac KA. Plant DNA methyltransferases. Plant Mol Biol. 2000;43(2-3):189-201.

Cao X, Jacobsen SE. Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Curr Biol. 2002;12(13):1138-44.

Papa CM, Springer NM, Muszynski MG, Meeley R, Kaeppler SM. Maize chromomethylase Zea methyltransferase2 is required for CpNpG methylation. Plant Cell. 2001;13(8):1919-28.

Finnegan EJ, Dennis ES. Isolation and identification by sequence homology of a putative cytosine methyltransferase from Arabidopsis thaliana. Nucleic Acids Res. 1993;21(10):2383-8.

Wada Y, Ohya H, Yamaguchi Y, Koizumi N, Sano H. Preferential de novo methylation of cytosine residues in non-CpG sequences by a domains rearranged DNA methyltransferase from tobacco plants. J Biol Chem. 2003;278(43):42386-93.

Genger RK, Kovac KA, Dennis ES, Peacock WJ, Finnegan EJ. Multiple DNA methyltransferase genes in Arabidopsis thaliana. Plant Mol Biol. 1999;41(2):269-78.

Bernacchia G, Primo A, Giorgetti L, Pitto L, Cella R. Carrot DNA-methyltransferase is encoded by two classes of genes with differing patterns of expression. Plant J. 1998;13(3):317-29.

Pradhan S, Cummings M, Roberts RJ, Adams RL. Isolation, characterization and baculovirus-mediated expression of the cDNA encoding cytosine DNA methyltransferase from Pisum sativum. Nucleic Acids Res. 1998;26(5):1214-22.

Steward N, Kusano T, Sano H. Expression of ZmMET1, a gene encoding a DNA methyltransferase from maize, is associated not only with DNA replication in actively proliferating cells, but also with altered DNA methylation status in cold-stressed quiescent cells. Nucleic Acids Res. 2000;28(17):3250-9.

Cao X, Springer NM, Muszynski MG, Phillips RL, Kaeppler S, Jacobsen SE. Conserved plant genes with similarity to mammalian de novo DNA methyltransferases. Proc Natl Acad Sci U S A. 2000;97(9):4979-84.

Cheng X. DNA modification by methyltransferases. Curr Opin Struct Biol. 1995;5(1):4-10.

Sethmann S, Ceglowski P, Willert J, Iwanicka-Nowicka R, Trautner TA, Walter J. M.(phi)BssHII, a novel cytosine-C5-DNA-methyltransferase with target-recognizing domains at separated locations of the enzyme. EMBO J. 1999;18(12):3502-8.

Mi S, Roberts RJ. How M.MspI and M.HpaII decide which base to methylate. Nucleic Acids Res. 1992;20(18):4811-6.

Yen RW, Vertino PM, Nelkin BD, Yu JJ, el-Deiry W, Cumaraswamy A, Lennon GG, Trask BJ, Celano P, Baylin SB. Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res. 1992;20(9):2287-91.

Bestor T, Laudano A, Mattaliano R, Ingram V. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988;203(4):971-83.

Teerawanichpan P, Chandrasekharan MB, Jiang Y, Narangajavana J, Hall TC. Characterization of two rice DNA methyltransferase genes and RNAi-mediated reactivation of a silenced transgene in rice callus. Planta. 2004;218(3):337-49.

Wada Y, Miyamoto K, Kusano T, Sano H. Association between up-regulation of stress-responsive genes and hypomethylation of genomic DNA in tobacco plants. Mol Genet Genomics. 2004;271(6):658-66.

Leonhardt H, Page AW, Weier HU, Bestor TH. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell. 1992;71(5):865-73.

Robertson KD, Jones PA. DNA methylation: past, present and future directions. Carcinogenesis. 2000;21(3):461-7.

Milutinovic S, Zhuang Q, Niveleau A, Szyf M. Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem. 2003;278(17):14985-95.

Vertino PM, Sekowski JA, Coll JM, Applegren N, Han S, Hickey RJ, Malkas LH. DNMT1 is a component of a multiprotein DNA replication complex. Cell Cycle. 2002;1(6):416-23.

Okuwaki M, Verreault A. Maintenance DNA methylation of nucleosome core particles. J Biol Chem. 2004;279(4):2904-12.

Ronemus MJ, Galbiati M, Ticknor C, Chen J, Dellaporta SL. Demethylation-induced developmental pleiotropy in Arabidopsis. Science. 1996;273(5275):654-7.

Finnegan EJ, Peacock WJ, Dennis ES. Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development. Proc Natl Acad Sci U S A. 1996;93(16):8449-54.

Kankel MW, Ramsey DE, Stokes TL, Flowers SK, Haag JR, Jeddeloh JA, Riddle NC, Verbsky ML, Richards EJ. Arabidopsis MET1 cytosine methyltransferase mutants. Genetics. 2003;163(3):1109-22.

Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 1992;69(6):915-26.

Bartee L, Bender J. Two Arabidopsis methylation-deficiency mutations confer only partial effects on a methylated endogenous gene family. Nucleic Acids Res. 2001;29(10):2127-34.

Henikoff S, Comai L. A DNA methyltransferase homolog with a chromodomain exists in multiple polymorphic forms in Arabidopsis. Genetics. 1998;149(1):307-18.

Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen SE. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science. 2001;292(5524):2077-80.

Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science. 2001;292(5514):110-3.

Jackson JP, Lindroth AM, Cao X, Jacobsen SE. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature. 2002;416(6880):556-60.

Giannino D, Mele G, Cozza R, Bruno L, Testone G, Ticconi C, Frugis G, Bitonti MB, Innocenti AM, Mariotti D. Isolation and characterization of a maintenance DNA-methyltransferase gene from peach (Prunus persica [L.] Batsch): transcript localization in vegetative and reproductive meristems of triple buds. J Exp Bot. 2003;54(393):2623-33.

Tariq M, Saze H, Probst AV, Lichota J, Habu Y, Paszkowski J. Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. Proc Natl Acad Sci U S A. 2003;100(15):8823-7.

Kato M, Miura A, Bender J, Jacobsen SE, Kakutani T. Role of CG and non-CG methylation in immobilization of transposons in Arabidopsis. Curr Biol. 2003;13(5):421-6.

Cao X, Aufsatz W, Zilberman D, Mette MF, Huang MS, Matzke M, Jacobsen SE. Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Curr Biol. 2003;13(24):2212-7.

Mathieu O, Bender J. RNA-directed DNA methylation. J Cell Sci. 2004;117(Pt 21):4881-8.

Hamilton A, Voinnet O, Chappell L, Baulcombe D. Two classes of short interfering RNA in RNA silencing. EMBO J. 2002;21(17):4671-9.

biopolym.cell-2005-21-6-cover.png

Downloads

Published

2005-11-20

Issue

Vol. 21 No. 6 (2005)

Section

Reviews