Antiviral properties of de novo designed proteins based on the albeferon and the fragment LKDRHDF (30–36) from human interferon-α2
DOI:
https://doi.org/10.7124/bc.0005F9Abstract
Two biologically active de novo proteins, ABB1-11 and ABBI-1, were engineered by including the fragment LKDRHDF (30–36) from human interferon-α2 (HuJFN-α2) into the N- and C-termini of albeferon – de novo protein with predesigned structure and function. It was shown that both proteins prevented the destruction of the L-41 and VERO cell monolayers generated by cytopathical action of a virus with the efficiency of native HuIFN-α2 and did not possess cytotoxicological properties.References
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