Mass spectrometry (252Cf-PDMS) study of aminoglycoside antibiotics interaction with nucleic acid components

Authors

  • A. N. Kalinkevich Institute of Applied Physics, NAS of Ukraine 58, Petropavlivska Str., Sumy, Ukraine, 40030 Author
  • V. V. Pilipenko Institute of Applied Physics, NAS of Ukraine 58, Petropavlivska Str., Sumy, Ukraine, 40030 Author
  • T. G. Kalinichenko Institute of Applied Physics, NAS of Ukraine 58, Petropavlivska Str., Sumy, Ukraine, 40030 Author
  • L. F. Sukhodub Institute of Applied Physics, NAS of Ukraine 58, Petropavlivska Str., Sumy, Ukraine, 40030 Author

DOI:

https://doi.org/10.7124/bc.0005F1

Abstract

Relative affinity of the aminoglycoside antibiotic streptomycine to nucleosides – adenosine, uridine, guanosine, cytidine was studied by the plasma desorption mass spectrometry ( Cf-PDMS). It has been shown that the affinity decreases in the row Urd > Ado > Cyd >Guo.

References

Navashin SM, Fomina IP, Sazykin YO. Aminoglycoside antibiotics. M.: Meditsina, 1977; 273 p.

Wang H, Tor Y. Electrostatic Interactions in RNA Aminoglycosides Binding. J Am Chem Soc. 1997;119(37):8734–5.

Sannes-Lowery KA, Griffey RH, Hofstadler SA. Measuring dissociation constants of RNA and aminoglycoside antibiotics by electrospray ionization mass spectrometry. Anal Biochem. 2000;280(2):264-71.

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Published

2002-03-20

Issue

Vol. 18 No. 2 (2002)

Section

Biopolymers and Cell