Computer search for promoter-like sequences for RNA-polymerase II and potential peptides among Alu-repeats
DOI:
https://doi.org/10.7124/bc.0002AFAbstract
CAAC and TATA boxes typical on many eukaryotic RNA-polymerase II promoters are observed in the first monomer of Alu-repeats. The computer analysis has shown that these boxes are homological to corespondent functional sites. Open reading frames coding short peptides are found in the second monomer of Alu-repeats. Two major types of peptides are distinguished among these potential peptides. They contain up to 75 % of all the peptides and are called EAE and GG-peptides, respectively.References
Lewin B. Genes. (2nd Edition). New York, John Wiley & Sons, 1985; 734 p.
Shakhmuradov IA, Kolchanov NA, Omel'ianchuk LV. et al. Evolution of Alu repeats. Novosibirsk, 1987. 55. (Preprint. USSR Academy of Sciences, Institute of Cytology and Genetics).
Korneev SA. Repetitive sequences of the human genome. Genetika. 1988;24(6):965-79.
Elder JT, Pan J, Duncan CH, Weissman SM. Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA. Nucleic Acids Res. 1981;9(5):1171-89.
Limborska SA, Korneev SA, Maleeva NE, Slominsky PA, Jincharadze AG, Ivanov PL, Ryskov AP. Cloning of Alu-containing cDNAs from human fibroblasts and identification of small Alu+ poly(A)+ RNAs in a variety of human normal and tumor cells. FEBS Lett. 1987;212(2):208-12.
Solov'yev VV, Kel' AE, Rogozin IV, Kolchanov NA. Introduction to the theory of genetic texts. Novosibirsk, Izd-vo Novosib. un-ta, 1987; 92 p.
Berdichevskiĭ FB, Chumakov IM, Kiselev LL. Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins. Mol Biol (Mosk). 1988;22(3):794-801.
Fütterer J, Gordon K, Bonneville JM, Sanfaçon H, Pisan B, Penswick J, Hohn T. The leading sequence of caulimovirus large RNA can be folded into a large stem-loop structure. Nucleic Acids Res. 1988;16(17):8377-90.
Allison LA, Moyle M, Shales M, Ingles CJ. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases. Cell. 1985;42(2):599-610.
