Antioxidant activity evaluation of derivatives with 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine scaffold
DOI:
https://doi.org/10.7124/bc.000A74Keywords:
6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine, antiradical/scavenging activity, DPPH, IC50, SARAbstract
Aim. Study of antioxidant (antiradical) activity of 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine derivatives. Methods. In vitro study of antiradical/scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals inhibition assay; IC50 values determination. Results. The series of 29 modified derivatives of 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine were evaluated for their ability to scavenge DPPH radicals in conditions close to physiological at 5 mM concentration and for the most promising compounds the IC50 values were determined using the serial dilutions method. The structure - antiradical activity correlations were performed and possible mechanisms of action were discussed. Conclusions. Tested 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine derivatives possess a moderate level of antiradical/scavenging activity.References
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