Influence of 2\', 5\' oligoadenylates and theirs analogues on the cyclic nucleotides level in vivo and in vitro

Tkachuk, Z. Yu.; Tkachuk, V. V.; Tkachuk, L. V.; Semernikova, L. I.; Matsuka, G. Kh.

doi:10.7124/bc.0005CD

Biopolym. Cell. 2001; 17(5):411-416.

http://dx.doi.org/10.7124/bc.0005CD

Structure and Function of Biopolymers

Influence of 2', 5' oligoadenylates and theirs analogues on the cyclic nucleotides level in vivo and in vitro

1Tkachuk Z. Yu., 1Tkachuk V. V., 1Tkachuk L. V., 1Semernikova L. I., 1Matsuka G. Kh.

Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

It was demonstrated that 2', 5' A analogues, when introduced to organs and tissues in animals, influenced the concentration of cAMP but not cGMP. The effect depends on the concentration and, therefore, one can employ the method of testing cAMP to determine the specific action of 2', 5' A analogues, which could be used at organ transplantation and allergy.

Full text: (PDF, in Ukrainian)

References

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