Biopolym. Cell. 2020; 36(3):163-181.
Обзоры
Кольцевые РНК – “кольца власти” над клеткой
1Гордиюк В. В., 1Маньковская О. С.
  1. Институт молекулярной биологии и генетики НАН Украины
    ул. Академика Заболотного, 150, Киев, Украина, 03143

Abstract

Кольцевые РНК (circRNA) являются эндогенными ковалентно замкнутыми одноцепочечными некодирующими РНК (ncRNA), не имеющими 5’-КЭПа и 3’-полиаденилирования, которые образуются в результате различных вариаций альтернативного сплайсинга мРНК. Экспрессию кольцевых РНК было обнаружено у представителей всех групп эволюционного древа жизни, включая вирусы и прокариоты. Эти молекулы являются эволюционно консервативными. Кольцевые РНК играют постоянную и универсальную биологическую роль. В данном обзоре мы обобщили последнюю имеющуюся информацию о кольцевых РНК и выделили их важнейшие и наиболее изученные функции в различных биологических процессах.
Keywords: кольцевые РНК, РНК-связывающие белки (RBPs), модель бэк сплайсинга, модель лассо, циркулирующая внеклеточная РНК, circRNA, ассоциированные с раком.

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