Biopolym. Cell. 2020; 36(3):163-181.
Circular RNA: the rings of power over cell
1Gordiyuk V. V., 1Mankovska O. S.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03143


Circular RNAs (circRNAs) are the endogenous covalently closed single-stranded noncoding RNAs (ncRNAs) without the 5′-cap and 3′-poly(A) tail, which are derived from different variations of alternative mRNA splicing. CircRNAs are expressed across all branches of evolutionary tree of life, including viruses and prokaryotes and are evolutionary conserved. CircRNAs play constitutive and universal biological roles. In this review we summarized the latest information about circRNAs and highlighted their most important and studied functions in different biological processes.
Keywords: Circular RNA (circRNA), RNA binding proteins (RBPs), backsplicing model, lariat model, the circulating cell-free RNA, cancer-related circRNA


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