Biopolym. Cell. 1993; 9(6):92-95.
Recombination analysis of complex allelic relations of lethal mutation induced in Drosophila by polynucleotides
- Institute of Plant Physiology and Genetics, NAS of Ukraine
31/17, Vasylkivska, Kyiv, Ukraine, 03022
Allelic relationships of the mutations induced by synthetic polynucleotides are of a rather specific and complex pattern. A general hypothesis has been suggested to explain the complex complementatory relations of lethal mutations. According to this hypothesis, specific interactions of these mutations reflect certain structural peculiarities of chromosomes connected with a multiplicity of defects. Existence of chromosomes with multiple mutations has been proved by the recombination analysis.
 Inge-Vechtomov SG. Introduction to molecular genetics. M.: Vyssh. shk., 1983; 343 p.
 Gershenzon SM. Induction of lethal mutations by means OF DNA preparations in drosophila melanogaster. Zh Obshch Biol. 1964;25:371-5.
 Gershenson SM, Alexandrov YuN, Malyuta SS. Mutagenic Effect of DNA and viruses in Drosophila. Kiev: Naukova Dumka, 1975; 160 p.
 Alexandrov YuN, Gershenson SM. Mutagenic effect of two synthetic polynucleotides and its high specificity. Mol Biol (Mosk). 1982;16 (3):16-9.
 Rodin SN. Analysis of allelic relationships among recessive lethals induced in Drosophila by exogenous DNA and by some viruses. Genetika. 1974; 10(9):94-105.
 Rodin SN, Mirkin BG. On the mathematical treatment of matrices allelism. Posts. I. Construction and interpretation of complementation maps. Issues. mat. Genetics. Novosibirsk: Institute of Cytology and Genetics, SB Academy of Sciences USSR, 1974: 198-213.
 Mirkin BG, Rodin SN. Graphs and genes. Using graphs to analyze the structure of the functions and evolution of genetic systems. Moscow: Nauka, 1977. 240 p.
 Rodin SN. Idea of coevolution. Nauka, Novosibirsk, 1991. 268 p.
 Alexandrov YuN, Gershenson SM, Maliuta SS. Mutagenic properties of DNA- and RNA-containing viruses, nonvirulent for Drosophila. Genetika. 1971; 7(9):102-12.
 Aleksandrov YuN, Golubovsky MD. The role of viruses and foreign DNA in natural mutation process: experimental studies on Drosophila. Genetika. 1983; 19(11):1818-27.
 Gershenson SM, Alexandrov YuN. Mutagenic effect of natural and synthetic polynucleotides and problem of directed mutations. Zh Obshch Biol. 1982; 43(6):747-63
 Alexandrov YuN, Gershenson SM. Selectivity of mutagenic action of synthetic polynucleotides. Biopolym Cell. 1985; 1(1):21-5.