Biopolym. Cell. 1992; 8(6):41-43.
http://dx.doi.org/10.7124/bc.000340
Structure and Function of Biopolymers
Vitamin D3 and 1,25-dihydroxyvitamin D3 –inhibitors of 5-lipoxygenase
1Bondarenko L. B., 1Harchenko O. V., 1Butovich I. A.
  1. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094

Abstract

The influence of vitamin D3 and 1,25-(OH)2D3 on the activity of potato 5-lipoxygienase and soy beans 15-lipoxygenase was examined. The inhibitory effect of these compounds on 5-lipoxygenase was established but not 15-lipoxygenase. 1,25-(OH)2D3 was stronger as an inhibitor then vitamin D3. Inhibitory effect of both compounds depended on dose of substrate (linoleic acid).
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References

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