Biopolym. Cell. 1992; 8(4):33-38.
Structure and Function of Biopolymers
Possibility of cytochrome C1 coding in mammalian mitochondrial genome
1Beregovskaya N. N., 1Savich A. V.
  1. Science and Engineering Center automated biotechnical systems "SONAR"
    Vladimirskaya Str., 41, Kiev, 252034


The amino acid sequences are compaired and the homology indexes are calculated for cytochromes of C1-type and for ND6 proteins coded on the mitochondrial genome. The ND6 proteins have greatest homology index with the cytochrome C1. In mitochondrial genome the gene coding the ND6 protein is arranged next to the gene coding the cytochrome b, a component of the 2nd complexes of respiratory chain, in which is contain also the cytochrome C1.


[1] Clary DO, Wolstenholme DR. The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code. J Mol Evol. 1985;22(3):252-71.
[2] Savich AV, Beregovskaya NN. Evolution and variability of cell energy system proteins. Biol Zh Armenii. 1989; 42(9-10):822-9.
[3] Beregovskaya NN, Savich AV. Possibility of iron-sulfur proteins coding in mammalian mitochondrial genome. Biopolym Cell. 1988; 4(5):238-45.
[4] Roe BA, Ma DP, Wilson RK, Wong JF. The complete nucleotide sequence of the Xenopus laevis mitochondrial genome. J Biol Chem. 1985;260(17):9759-74.
[5] Wakabayashi S, Matsubara H, Kim CH, Kawai K, King TE. The complete amino acid sequence of bovine heart cytochrome C1. Biochem Biophys Res Commun. 1980;97(4):1548-54.
[6] Dayhof VO, Hunt TL. Protein sequence database. Washington: O. C., 1981. 265 p.
[7] Narita K, Titani K. Comparison of the primary structures of cytochromes C from two species of yeast. Proc Jap Acad. 1985; 9: 831-6.
[8] Dickerson RE, Timkovich R, Almassy RJ. The cytochrome fold and the evolution of bacterial energy metabolism. J Mol Biol. 1976;100(4):473-91.