Biopolym. Cell. 1991; 7(6):15-32.
Structure and Function of Biopolymers
The possibilities of the soft-ionization mass-spectrometry in the molecular-biological studies
1Sukhodub L. F.
  1. Institute of Applied Physics, NAS of Ukraine
    58, Petropavlivska Str., Sumy, Ukraine, 40030

Abstract

The results which demonstrate the possibilities of the soft-ionization mass-spectrometry (SI-MS) for molecular-biological studies in two direction–thermodynamic and analytical-structural are given. The method of the temperature-dependent field ionization mass-spectrometry which was the first time used for measuring of the thermodynamic characteristics of the number biological associates: Watson-Crick, mispairing and other base pairs, «aminoacid-base» complexes, hydrates of the bases and their pairs are described. The possibilities of the SI-MS for study of the hydrolysis the antitumour drugs in the physiological solutions and adducts of their interactions with DNA are shown.

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