Biopolym. Cell. 1991; 7(1):55-62.
Structure and Function of Biopolymers
Low-frequency raman spectra of some methylated components of nucleic acisds: 1-methyl derivatives of pyrimidine bases
1Govorun D. N., 1Mishchuk Ya. R., 1Zheltovsky N. V.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR

Abstract

Low-frequency (10–15 cm–1 < v < 200 cm–1) Raman spectra of polycrystalline 1-methyl-cytosine, 1-methyluracil and 1-methylthymine at 300 K have been investigated in detail. The lattice vibrational modes and intramolecular out-of-plane vibrations have been identified. It has been discussed, how the low frequency Raman spectra of nucleic acid bases are affected by their methylation at the point of glycoside linkage.

References

[1] Govorun DN, Mishchuk YaR, Zheltovsky NV. Low-frequency raman spectra of some methyl-substituted components of nucleic acids: 9-methyl derivatives of pyrimidine bases. Biopolym Cell. 1991; 7(2):5-8.
[2] Lord RC, Thomas GJ. Raman spectral studies of nucleic acids and related molecules—I Ribonucleic acid derivatives. Spectrochimica Acta Part A: Molecular Spectroscopy. 1967;23(9):2551–91.
[3] Harada I, Lord RC. Low-frequency infrared and Raman spectra of some adenine and uracil crystals. Spectrochimica Acta Part A: Molecular Spectroscopy. 1970;26(12):2305–18.
[4] Colombo L, Kirin D. Raman spectrum of 1-methyl-uracil single crystal. Interpretation of internal and external spectra. Spectrochim Acta A. 1986;42(4):557–65.
[5] Lewis TP, Miles HT, Becker ED. Infrared and Raman spectra and vibrational assignments for 1-methyluracil and isotopic derivatives. J Phys Chem. 1984;88(15):3253–60.
[6] Wójcik MJ. Low-frequency vibrational spectra of crystalline uracil, thymine and their 1-methyl-derivatives. J Mol Struct. 1988;189(1-2):239–42.
[7] Fan K, Boggs JE. Analysis of the vibrational spectra of 1-methyluracil and its isotopic derivatives by ab initio calculations. J Mol Struct. 1986;139(3-4):283–303.
[8] Szczesniak M, Nowak MJ, Szczepaniak K, Person WB. Effect of intermolecular interactions on the infrared spectrum of 1-methyluracil. Spectrochim Acta A. 1985;41(1-2):237–50.
[9] Maleyev VYA, Stanevich AE. The absorption spectra of crystals of bases in the far infrared. Spectroscopy in solids. Leningrad: Nauka, 1969; vol. 4:95-100.
[10] Beetz CP, Ascarelli G. The low frequency vibrations of pyrimidine and purine bases. Spectrochim Acta A. 1980;36(3):299–313.
[11] Bandekar J, Zundel G. Normal coordinate analysis treatment on uracil in solid state. Spectrochim Acta A. 1983;39(4):343–55.
[12] Harsanyi L, Csacza P. Theoretical force field and vibrational spectrum of uracil by the CNDO. 2 force method. Acta Chim Acad Sci Hung. 1983; 113(3):257-278.
[13] Barnes AJ, Stuckey MA, Le Gall L. Nucleic acid bases studied by matrix isolation vibrational spectroscopy: Uracil and deuterated uracils. Spectrochim Acta A. 1984;40(5):419–31.
[14] Kirin D, Colombo L, Furić K, Meier W. Low-frequency vibrational spectrum of the 1-methyl-thymine single crystal. Spectrochim Acta A. 1975;31(11):1721–7.
[15] Kyogoku Y, Higuchi S, Tsuboi M. Intra-red absorption spectra of the single crystals of 1-methyl-thymine, 9-methyladenine and their 1:1 complex. Spectrochim Acta A. 1967;23(4):969–83.
[16] Csaszar P, Harsanyi L, Boggs JE. Vibrational frequencies and assignments for some isotopomers of urcail using a scaled ab initio force field. Int J Quant Chem. 1988;33(1):1–17.
[17] Berreby L. Freymann R. Donnees preliminaires sur l'etude de la liaison hydrogene dans les bases azotees et les nucleosides par cryospectroscopie dans Pinfrarouge loin tain. C. r. Acad. Sci. 1971; 272B(13):111-4.
[18] Govorun DN, Mishchuk YaR, Zheltovsky NV. Low-frequency phonon raman spectra of nucleic acid constituents: pyrimidine bases. Biopolym Cell. 1990; 6(3):31-39.