Biopolym. Cell. 1991; 7(1):38-39.
Computer search for promoter-like sequences for RNA-polymerase II and potential peptides among Alu-repeats
1Malchenko S. Z.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR


CAAC and TATA boxes typical on many eukaryotic RNA-polymerase II promoters are observed in the first monomer of Alu-repeats. The computer analysis has shown that these boxes are homological to corespondent functional sites. Open reading frames coding short peptides are found in the second monomer of Alu-repeats. Two major types of peptides are distinguished among these potential peptides. They contain up to 75 % of all the peptides and are called EAE and GG-peptides, respectively.


[1] Lewin B. Genes. (2nd Edition). New York, John Wiley & Sons, 1985; 734 p.
[2] Shakhmuradov IA, Kolchanov NA, Omel'ianchuk LV. et al. Evolution of Alu repeats. Novosibirsk, 1987. 55. (Preprint. USSR Academy of Sciences, Institute of Cytology and Genetics).
[3] Korneev SA. Repetitive sequences of the human genome. Genetika. 1988;24(6):965-79.
[4] Elder JT, Pan J, Duncan CH, Weissman SM. Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA. Nucleic Acids Res. 1981;9(5):1171-89.
[5] Limborska SA, Korneev SA, Maleeva NE, Slominsky PA, Jincharadze AG, Ivanov PL, Ryskov AP. Cloning of Alu-containing cDNAs from human fibroblasts and identification of small Alu+ poly(A)+ RNAs in a variety of human normal and tumor cells. FEBS Lett. 1987;212(2):208-12.
[6] Solov'yev VV, Kel' AE, Rogozin IV, Kolchanov NA. Introduction to the theory of genetic texts. Novosibirsk, Izd-vo Novosib. un-ta, 1987; 92 p.
[7] Berdichevski? FB, Chumakov IM, Kiselev LL. Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins. Mol Biol (Mosk). 1988;22(3):794-801.
[8] F?tterer J, Gordon K, Bonneville JM, Sanfa?on H, Pisan B, Penswick J, Hohn T. The leading sequence of caulimovirus large RNA can be folded into a large stem-loop structure. Nucleic Acids Res. 1988;16(17):8377-90.
[9] Allison LA, Moyle M, Shales M, Ingles CJ. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases. Cell. 1985;42(2):599-610.