Biopolym. Cell. 1990; 6(6):89-92, 99.
Structure and Function of Biopolymers
Acidic polypeptides as inhibitors of the repair of double-strand DNA breaks
1Medvedev A. I., 1Revina G. I.
  1. Institute of Biological Physics, Academy of Sciences of the USSR
    Pushchino, Moscow Region, USSR


The ability of polypeptides consisting of aspartic and glutamic acids to inhibit the repair of double-strand DNA breaks induced in Y-irradiated Chinese hamster and HeLa cells was shown. A complete inhibiton of the double-strand DNA breaks repair was observed under the concentrations of 20 jimoles/1 (polyglutamic acid with molecular weight 2000–15000 daltons) and 100 umoles/1 (aspartylglutamic acid with moSccuar weight 1500-4500 daltons). Both polypeptides were low toxic at the given concentrations, their inhibitory effect being reversible.


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