Biopolym. Cell. 1990; 6(3):70-74.
Cell Biology
Role of the nucleocytoplasmic ratio in regulation of the mammalian development. Development of the embryos with the doubled cytoplasm volume
1Evsykov S. V., 1Morozova L. M., 1Solomko A. P.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR


Certain blastomeres of the two-cell mouse embryos and blastomeres with the doubled cytoplasm volume have been compared as to their development in vitro. A decrease of the nucleocytoplasmic ratio had no effect on the rate of embryo cleavage, but the blastocoele appearance was 10 h delayed with more cleavage divisions than in control. The presented hypothesis suggests that the change of cellular morphogenetic programs requires definite concentration of substances — products of the previously realized program.


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