Biopolym. Cell. 1989; 5(1):84-86.
Short Communications
Protein biosynthesis in the cell-free protein-synthesizing systems from rabbit myocardium during total ischemia
2Maskoliunas R. K., 2Liekis A. V., 1Kovalenko M. I.
  1. Institute of Molecular Biology and Genetics, Academy of Sciences of the Ukrainian SSR
    Kiev, USSR
  2. Medical Institute Kaunas
    Kaunas, USSR


A decrease of the total protein synthesis in various cell-free systems and a marked increase in the time of «average» polypeptide chain synthesis are found in the case of reversible and irreversible ischcmic damage of the rabbit myocardium. One of the reasons of myocardium protein synthesis decay is established to be functional changes in ribosomes during ischemia.


[1] Irgashev ShB. Features of protein synthesis in the heart and liver in experimental myocardial infarction. Cardiology Update. Tashkent, Tashkent med. Inst. Press, 1980; 34-5.
[2] Ivanov LL, Tamuliavichius AA, Lukoshiavichius LIu, Kovalenko MI, Rodovichius GA. Aminoacyl-tRNA-synthetases and their high molecular weight complexes in experimental myocardial ischemia. Mol Biol (Mosk). 1984;18(5):1326-9.
[3] Kovalenko MM, Rodovichius GA, Tamuliavichius AI, Pivoryunayte II, Lukoshyavichius LYu, Prashkyavichius AK. et al. Study of the molecular basis of disorders of protein biosynthesis in experimental myocardial infarction and myocardial autolysis. Molekularnaya biologiya (Kiev). 1984; Is. 37:18-21.
[4] Armiger LC, Seelye RN, Carnell VM, Smith CU, Gavin JB, Herdson PB. Morphologic and biochemical changes in autolysing dog heart muscle. Lab Invest. 1976;34(4):357-62.
[5] Borgers M, Shu LG, Xhonneux R, Thon? F, Van Overloop P. Changes in ultrastructure and Ca2+ distribution in the isolated working rabbit heart after ischemia. A time-related study. Am J Pathol. 1987;126(1):92-102.
[6] Jennings RB, Ganote CE. Structural changes in myocardium during acute ischemia. Circ Res. 1974;35 Suppl 3:156-72.
[7] Lekis AV, Lukoshevichius LYu, Kovalenko MI, Buldakova OV. Study of the molecular mechanisms of hypoalbuminemia under experimental myocardial infarction. Biopolym. Cell. 1985; 1(6):322-7.
[8] Iavich MP, Lerman MI. Cell-free system of protein synthesis from rat's cardiac muscle. Vopr Med Khim. 1976;22(3):307-11.
[9] Leytin VL, Lerman MI. Methods for determining the average time in synthesis of a polypeptide chain. Modern methods in biochemistry. Moscow, Medicine, 1977; 277-285.