Biopolym. Cell. 1988; 4(4):188-192.
Structure and Function of Biopolymers
Thermal characteristics of chromatin, nuclei and DNA of BalB and C3HA mice which were given Ni2+ ions
1Patiashvili L. J., 1Monaselidze J. R., 1Chanchalashvili Z. I., 1Chitadze G. Sh., 1Majagaladze G. V., 1Lomidze E. M.
  1. Institute of Physics, Academy of Sciences of the Georgian SSR
    Tbilisi, USSR


The method of differential scanning microcalorimelry (DSM) is used to find those minute changes which arise in active chromatin DNA of tumour cells and nuclei as a result of Ni2+ ions penetration into the DNA structure. Chromatin native structure is established to be considerably destructed by the incorporation of Ni2+ ions in chromatin DNA of cells. The comparative analysis of melting process of DNA isolated from tumour cells of mice which were given and not given Ni2+ ions showed that the changes in the chromatin structure are closely related to the DNA double helix damage.


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