Biopolym. Cell. 1988; 4(4):188-192.
Structure and Function of Biopolymers
Thermal characteristics of chromatin, nuclei and DNA of BalB and C3HA mice which were given Ni2+ ions
- Institute of Physics, Academy of Sciences of the Georgian SSR
The method of differential scanning microcalorimelry (DSM) is used to find those minute changes which arise in active chromatin DNA of tumour cells and nuclei as a result of Ni2+ ions penetration into the DNA structure. Chromatin native structure is established to be considerably destructed by the incorporation of Ni2+ ions in chromatin DNA of cells. The comparative analysis of melting process of DNA isolated from tumour cells of mice which were given and not given Ni2+ ions showed that the changes in the chromatin structure are closely related to the DNA double helix damage.
 Georgiev GP, Bakaev VV. Three levels of structural organization of the eukaryotic chromosomes. Mol Biol (Mosk). 1978;12(6):1205-30.
 Brown WM, George M Jr, Wilson AC. Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci U S A. 1979;76(4):1967-71.
 Fedorov NA. DNA as the principal target for carcinogenic, mutagenic and antineoplastic drugs. Usp Sovrem Biol. 1981;91(1):61-73.
 Fedorov NA. DNA structure and cells transformation. Moscow, Medicine, 1983; 254 p.
 Andronikashvili EL, Chanchalashvili ZI, Madzhagaladze GV, Monaselidze DR. Thermal properties of the soluble chromatin and DNA of normal and tumor cells. Mat. Meet. by conformational changes of biopolymers in solution. Tbilisi: Metsniyereba, 1975; Vol. 2:161-71.
 Chanchalashvili ZI, Madzhagaladze GV, Mgeladze GN, Monaselidze DR.Microcalorimetric study dilute solutions of DNA isolated from normal and tumor tissues. Mat. Meet. by conformational changes of biopolymers in solution. Tbilisi: Metsniyereba, 1975; Vol. 3:84-5.
 Monaselidze DR, Chanchalashvili ZI, Mgeladze GN et al. Microcalorimetric study of the DNA of normal and tumor tissues at high salt concentrations Cs2S04. VII All-Union conf. by calorimetry: Proc. of reports. Chernogolovka, 1977; 415-9.
 Zhizhina GP, Bobovich SI, Petrov OE, Kurgliakova KE. Kinetic study of the physicochemical properties of normal and neoplasm DNA. Dokl Akad Nauk SSSR. 1974;217(3):722-5.
 Andronikashvili EL, Monaselidze DR. Thermal properties of chromatin and DNA molecules isolated from normal and transformed cells. Symp. Genetique-Cancer-Environment: Abstr. Monaco, 1982:35.
 Andronikashvili EL, Mosulishvili LM, Mandzhgaladze VP, Belokobyl'skii AI, Kharabadze NE. Binding of trace quantities of some elements by malignant tumor nucleic acids. Dokl Akad Nauk SSSR. 1970;195(4):979-82.
 Monaselidze DR, Bakradze G. Adiabatic differential microcalorimeter. Conformational changes of biopolymers in solution. Moscow, Nauka, 1973; 196-9.
 Loeb JE, Chauveau J. Preparation of DNA by filtration on agarose gel. Biochim Biophys Acta. 1969;182(1):225-34.
 Monaselidze DR, Chanchalashvili ZI, Dzhokhadze DI, Mrevlishvili GM. Thermal properties of of intact cell nuclei. VI All-Union conf. on calorimetry: Proc. of reports. Tbilisi, 1973; 501-5.
 Monaselidze JR, Chanchalashvili ZI, Mgeladze GN, Madjagaladze GV, Chitadze GSh. Thermal properties of intact nucleoproteids. J Polymer Sci. 1981; 69(1):17-20.
 Andronikashvili EL, Monaselidze DR, Chanchalashvili ZI, Madzhagaladze GV. Cooperative thermal transitions in normal and tumor cells. Biofizika. 1983;28(3):528-37.
 Andronikashvili EL. Changes in the physicochemical properties of proteins macromolecules and nucleic acids extracted from normal and tumor tissues. IV Int. Biophysical congr. Pushchino, 1973; Vol. 4:152-75.