Biopolym. Cell. 2022; 38(3):205-212.
Bioorganic Chemistry
Antioxidant activity evaluation of derivatives with 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine scaffold
1Slyvka N. Yu., 1, 2Holota S. M., 1Saliyeva L. M., 1Kadykalo E. M., 2Kolishetska M. A., 3Vovk M. V.
  1. Lesya Ukrainka Volyn National University
    13, Voli Ave., Lutsk, Ukraine, 43025
  2. Danylo Halytsky Lviv National Medical University
    69, Pekarska Str., Lviv, Ukraine, 79010
  3. Institute of Organic Chemistry, NAS of Ukraine
    5, Murmanska Str., Kyiv, Ukraine, 02660


Aim. Study of antioxidant (antiradical) activity of 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine derivatives. Methods. In vitro study of antiradical/scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals inhibition assay; IC50 values determination. Results. The series of 29 modified derivatives of 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine were evaluated for their ability to scavenge DPPH radicals in conditions close to physiological at 5 mM concentration and for the most promising compounds the IC50 values were determined using the serial dilutions method. The structure - antiradical activity correlations were performed and possible mechanisms of action were discussed. Conclusions. Tested 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine derivatives possess a moderate level of antiradical/scavenging activity.
Keywords: 6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine, antiradical/scavenging activity, DPPH, IC50, SAR


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