Biopolym. Cell. 2017; 33(5):393-400.
Biomedicine
Association of genetic polymorphism with the mutation status of the BRCA1/2 genes in spontanous breast cancer
1Polinyk S. I., 1Rybchenko L. A., 1Klymenko S. V., 2Zaharceva L. M., 3Klimuk B. T.
  1. State Institution "National Research Center for Radiation Medicine, NAMS of Ukraine"
    53, Melnykova Str., Kyiv, Ukraine, 04050
  2. Bogomolets National Medical University
    13, Shevchenko Blvd., Kyiv, Ukraine, 01601
  3. National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"
    37, Pobedy Av., Kyiv, Ukraine, 03056

Abstract

Aim. To study ssociation of the FGFR2 and TOX3/LOC643714 genetic polymorphisms with the BRCA1/2 mutation status in Ukrainian female breast cancer patients without ionizing radiation impact in their histories. Methods. Molecular genetics methods were used. Non-parametric data were evaluated using the two-way Fisher’s Exact test. Statistical analysis was performed using the StatPlus Pro program package. Results. Association of genetic polymorphisms rs2981582 of the FGFR2 gene and rs3803662 of the TOX3/LOC643714 gene with the mutation status of the BRCA1/2 genes in breast cancer patients non-treated with ionizing radiation in their histories was shown. Conclusion. The association between the minor genotype of the TOX3/LOC643714 gene and the positive status of the BRCA1 gene was found to be reliable. No statistic association was found between homozygotes for the major alleles and heterozygote polymorphisms of the FGFR2, TOX3 / LOC643714 genes, with or without BRCA1/2 mutations (p < 0.05).
Keywords: breast cancer, genetic polymorphisms, BRCA1/2 mutations

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