Biopolym. Cell. 2014; 30(5):335-342.
Structural plasticity of the nuclear envelope and the endoplasmic reticulum
1Sheval E. V., 1Musinova Y. R.
  1. A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
    Leninskie gory, house 1, building 40, Moscow, Russian Federation, 119992


The nuclear envelope is a double membrane structure, continuous with endoplasmic reticulum, and the morphological organization of both these structures is quite conservative. However, nuclear envelope and endoplasmic reticulum demonstrate distinct structural plasticity, i. e., based on common organization, cells may form various non-canonical membrane structures that are observed only in specialized types of cells or appear in different pathologies. In this review, we will discuss the mechanisms of the biogenesis of such non-canonical structures, and the possible role of this plasticity in the development of pathological processes.
Keywords: nuclear envelope, endoplasmic reticulum, structural plasticity


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