Biopolym. Cell. 2014; 30(1):16-24.
The start of systems biology in Ukraine
1Obolenskaya M. Yu., 1Tokovenko B. T., 1Kuklin A. V., 1Frolova A. A., 1Rodriguez R. R., 1Dotsenko V. A., 1Dragushchenko O. O.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


The first laboratory of Systems Biology in Ukraine (IMBIG NASU) represents a track record of its scientific results. They include the pioneered development of a web-based tool for genome-wide surveys of eukaryotic promoters for the presence of transcription factors binding sites (COTRASIF); the deciphered mechanisms of the fine-tuned and balanced response of primary hepatocytes to interferon alpha levels recorded after partial hepatectomy; the elaboration of a novel method of gene regulatory network inference compatible with GRID environment and the development of a stoichiometric model of folate-related one carbon unit metabolism in human placenta and its application for the characteristics of the system’s behavior as a whole at different human pathologies.
Keywords: systems biology, gene regulatory network, metabolic modeling, microarray


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