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Structure and Function of Biopolymers
Specificity of interaction of qlycine and its methyl derivatives with nucleic acid base from nuclear magnetic resonance data
- Institute of Biological Physics, Academy of Sciences of the USSR
Pushchino, Moscow Region, USSR
Interaction of glycine and its O- and N-methyl derivatives with nucleic acid bases have been investigated by the NMR method. O-methylglycine selectively interacts with cytosine and guanine in dirnethylsulphoxide (DMSO) solution. Cytosine forms a complex where NH+3-group of O-methylglycine specifically interacts with O2 and N3 atoms with simultaneous formation of hydrogen bonding between carbonyl group and NH2-group of cytosine. For guanine the complex formation is, probably, due to interaction of NH+ group with O6, N7 atoms and hydrogen bonding of carbonyl group with Nl-H-group. The methylglycine derivatives form complexes with cytosine and guanine and compete for hydrogen bonds formation in guanine-cytosine pairs in DMSO: H2O (3:1) solutions. But O-methylglycine forms a complex preferably with cytosine, whereas N-methylglycine вЂ” with guanine. The data obtained indicate the interaction of glycine with cytidine, CMP and GMP in water.
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