Biopolym. Cell. 2013; 29(5):413-417.
Biomedicine
The distribution of allelic variants of genes HLA-DRB1, HLA-DQA1, HLA-DQB1 and HLA-G among women with idiopathic recurrent pregnancy loss
1Terpylyak O. I., 1Sosnina K. O., 1Zastavna D. V., 1Helner N. V., 1Mikula M. I.
  1. State Institution "Institute of Hereditary Pathology, NAMS of Ukraine"
    31a, M. Lysenko Str., Lviv, Ukraine, 79008

Abstract

Aim. Analyze the distribution of allelic polymorphism of HLA-DRB1, DQA1, DQB1 genes and HLA-G 14-bp insertion/deletion polymorphism in women with RPL. Methods. DNA extraction, PCR, agarose gel electrophoresis. Results. A comprehensive analysis of the distribution and frequency of allelic variants of genes HLA-DRB1, HLA- DQA1, HLA-DQB1 and HLA-G 14 bp insertion/deletion polymorphism among women with RPL. Conclusions. Changes in the major hystocompatibility complex genes can cause the failure of a woman’s reproductive function and lead to an early fetal loss.
Keywords: recurrent pregnancy loss, HLA-genotyping, HLA-G 14 bp insertion/deletion polymorphism

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