Biopolym. Cell. 2007; 23(2):115-121.
Biomedicine
Experimental model of autoimmune myosin-induced myocardium injury
1Bobyk V. I., 2Ryabenko D. V., 2Sergienko O. V., 2Trunina I. V., 1Fedorkova O. M., 1Morozova L. M., 1Sidorik L. L.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. National Scientific Center "M. D. Strazhesko Institute of Cardiology, MAS of Ukraine"
    5, Narodnogo Opolchennya Str., Kyiv, Ukraine, 03151

Abstract

Experimental model of autoimmune myosin-induced injury of BALB/c mouse myocardium, similar to human dilated cardio­myopathy (DCM), has been developed. The immunization by myosin, obtained from DCM-affected human heart initiated the following DCM-Uke myocardial damage: myocytolysis, cardioscle­ rosis, thinning of left ventricular wall, decrease in cardiac actomyosin ATP-ase activity and increase in anti-myosin autoantibodies level.
Keywords: dilated cardiomyopathy, autoantibodies, myosin, myo­cardial damage

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