Biopolym. Cell. 2006; 22(6):475-479.
Bioorganic Chemistry
Study of biological activity of some 4-S-derivatives of quinoline
1Gencheva V. I., 1Omelyanchik L. A., 2Fedoryak D. M., 1Brazhko A. A., 1Zavgorodny M. P.
  1. Zaporizhzhya National University
    Zhukovsky Str., 66, Zaporizhzhya, Ukraine, 69600
  2. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094


The biological action of (8-methoxy-2-methylquinoline-4-ilthio)-carboxylic acids was studied on the model of acute toxic hepatitis. The most expressed membrane stabilizing effect was observed for p-(8-methoxy-2-methylquinoline-4-ilthio) lactic acid which nor­malizes the level of enzymic activity and protein synthetic function of a liver. The investigated compounds are shown as perspective potential hepatoprotectors
Keywords: 4-S-derivatives of quinoline, membrane stabilizers, hepatoprotectors


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