Biopolym. Cell. 2004; 20(4):343-346.
Biomedicine
Research of antitumor ctivity of thioTEPA alkylated nucleic acid and nucleotides in vivo
1Voloshchuk T. P., 1Patskovskii Yu. V., 1Potopalskii A. I., 1Vorobyeva I. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

The antitumor activity of the thioTEPA alkylated DNA preparations of various origin (cattle spleen, salmon sperm, chicken erythrocytes), yeast RNA and mononucleotides - ATP and GTP has been established in the experiments in vivo on mice with interweave Ehrlich carcinoma. The therapeutic doses (100–300 mg/kg of the weight) of these preparations insured the tumor growth inhibition by 90–100 % at the toxic dose LD50 between 1.5 and 2 g/kg. The DNA preparations, modified by monofunctional alkylating agents (ethylenimine and monoaziridinediethylphosphate), have no noticeable antitumor effect.

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