Biopolym. Cell. 2004; 20(4):316-320.
Structure and Function of Biopolymers
Restoration of the activity of higler eukaryotic aminoacyl-tRNA synthetases and their stabilization in the presence of ribosomes
1Lukash T. O., 1Turkovskaya G. V., 1El'skaya A. V.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


The present work concerns the functional interaction between the rabbit liver ribosomes and aminoacyl-tRNA synthetases. We have shown that the ribosomes are able to stimulate the activity of leucyl-, isoleucyl- and phenylalanyl-tRNA synthetases. Possible mechanisms of this effect have been analysed. It is concluded, that the ribosomes have chaperone-like property in the maintenance of the ARS active conformation.


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