Biopolym. Cell. 2003; 19(6):548-552.
Bioorganic Chemistry
Antitumor activity among derivatives of the 3-chloro-4-(3-hydroxyanilino) -2,5-dihydropyrrole-2,5-dione
1Tarnavsky S. S., 1Dubinina G. G., 1Golovach S. M., 1Yarmoluk S. M.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680

Abstract

Fourteen derivatives of the 3-chloro-4-(3-hydroxyanilino)-2,5-di-hydropyrrole-2,5-dione with various substituents at 1 and 3 positions of maleimide cycle have been synthesized and tested for antitumor activity in vitro. Ten compounds have been selected after pre-screening and tested on 52 human tumor cell lines. It has been revealed that 1 -(2,3-dichlorophenyl)-3-chloro-4-(3-hydroxyanili-no)-2,5-dihydro-1H-2,5-pyrroledione and l-benzyl-3-(3-hydroxy-anilino)-4-phenylsulfanyl-2,5-dihydro-1H-2,5-pyrroledione suppress growth of some cancer cell lines with GI50 < 0.5 ·10–7 M and 10–8 M.

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