Biopolym. Cell. 2003; 19(5):445-450.
Molecular Mechanisms of Differentiation
A role of tyrosine kinase Syk during neuronal differentiation of raurine embryonal carcinoma cells P19, stimulated by retinoic acid
1, 2Kukharskyy V. M., 2Draberova E., 1, 3Blame Ya. B., 2Draber P.
- Taras Shevchenko National University of Kyiv
64, Volodymyrska Str., Kyiv, Ukraine, 01033 - Institute of Molecular Genetics of the ASCR
1083, Videnska, 142 20 Prague 4, Czech Republic - Institute of Cell Biology and Genetic Engineering, NAS of Ukraine
148, Akademika Zabolotnogo Str., Kyiv, Ukraine, 03680
Abstract
Using a culture of murine embryonal carcinoma cells stimulated by retinoic acid as a model of neuronal differentiation the changes in the tyrosine kinase Syk expression during neuronal differentiation have been shown. Study on the Syk tyrosine kinase distribution in both soluble and insoluble, enriched by elements of cytoskeleton, fractions of cells, has revealed first the endocellular redistribution of tyrosine kinase Syk during neuronal differentiation. A possible interaction of tyrosine kinase Syk with cytoskeleton elements is assumed.
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