Biopolym. Cell. 2003; 19(3):295-297.
Short Communications
Investigation of biological activity of antitroponin antibodies at dilated cardiomyopathy
1Fedorkova O. M., 1Bobyk V. I., 2Ryabenko D. V., 3Danilova V. M., 1Matsuka G. Kh., 1Sidorik L. L.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. M. D. Strazhesko Institute of Cardiology, MAS of Ukraine
    5, Narodnogo Opolchennya Str., Kyiv, Ukraine, 03151
  3. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601


The autoantibodies directed against several cardiomyocites proteins have been detected at human organospecific autoimmune disease – dilated cardiomyopathy (DCM). In the present work we investigated biological activity of monospecific antitroponin antibodies at DCM. The activating influence of these autoantibodies from DCM patients sera on the actomyosin ATPase activity has been found in vitro.


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