Biopolym. Cell. 2002; 18(4):267-271.
Interaction of recipient genome and transgenes in eukaryoles. Extrachromosomal transgenes
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
Two forms of transgenes are known – integrated into the host genome and extrachromosomal. Although the integrated transgenes are more widespread, the extrachromosomal ones are more interesting and promising for biotechnology and biomedicine. At the same time, the mechanisms determining the fate of the introduced DNA molecule, have not been studied entirely. In this review we discuss these mechanisms and analyze the extrachromosomal transgenes of different origin.
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