Biopolym. Cell. 2002; 18(3):237-242.
http://dx.doi.org/10.7124/bc.000604
Bioorganic Chemistry
New 6-azauracil derivatives – amides of as-triazine carbon acids: their synthesis and antimicrobial activity
1Alexeeva I. V., 1Palchikovskaya L. I., 2Harchenko S. N., 2Baschta E. V., 1Platonov M. O., 1Kostina V. G., 1Usenko L. S., 1Lysenko N. A., 2Malko V. A.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. National Agrarian University UAAN
    15, Heroyev Oborony Str., Kyiv, Ukraine, 03041

Abstract

Three series of new 6- azauracil derivatives, differing by structural motives of the spacer linking a heterocycle with carbamide fragments have been synthesized and researched on the basic principles of bioisosterism concept. The antimicrobial activity of these new compounds has been detected in test-cultures of bacteria, micelial and yeast-like fungi. The results obtained indicate that the 6-azauracil-5-propanic and 5-thioacetic acid derivatives can be modified to enhance significantly their antibacterial potency.
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