Biopolym. Cell. 2002; 18(2):114-116.
Mass spectrometry (252Cf-PDMS) study of aminoglycoside antibiotics interaction with nucleic acid components
- Institute of Applied Physics, NAS of Ukraine
58, Petropavlivska Str., Sumy, Ukraine, 40030
Relative affinity of the aminoglycoside antibiotic streptomycine to nucleosides – adenosine, uridine, guanosine, cytidine was studied by the plasma desorption mass spectrometry ( Cf-PDMS). It has been shown that the affinity decreases in the row Urd > Ado > Cyd >Guo.
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 Sannes-Lowery KA, Griffey RH, Hofstadler SA. Measuring dissociation constants of RNA and aminoglycoside antibiotics by electrospray ionization mass spectrometry. Anal Biochem. 2000;280(2):264-71.