Biopolym. Cell. 2002; 18(1):76-80.
Structure and Function of Biopolymers
Study on the structure of phosphatidylcholine-pyrazole and phosphatidylcholine-pyridine complexes
1Nasibullin R. S., 1Kosareva D. I., 1Serebrenik M. A., 1Spirikhin L. V.
  1. Bashkir State Medical University
    3, Lenin Str., Ufa, Bashkortostan, Russian Federation, 450000


The structure of phosphatidylcholine-pyrazole and phosphatidyl-choline-pyridwe complexes were studied using the quantum chemistry and C-NMR spectroscopy methods. Four sites of the geterocyclic molecule localization in the choline group of phosphati-dylcholine (PC) were detected. The complex containing the bio¬logically active molecule located near the NCH2 fragment of PC polar group was shown to be the most stable.


[1] Zheltovsky NV, Samiylenko SP, Kolomiets IN, Kondratyuk IV, Stepanyugin AV. The investigation of interactions of hypoxanthine, xanthine and their methyl and glycosyl derivatives with amino acid carboxylic group by spectroscopic methods. Biopolym Cell. 1993; 9(3):17-22.
[2] Govorun DM, Kondratyuk IV, Zheltovsky NV. Acidic-basic properties of molecular xanthine and its complex formation ability. Biopolym Cell. 1994; 10(6):61-4.
[3] Nasibullin RS, Spirichin LV, Ponomareva VA. Formation of pyrazole molecule-phospholipids complex. Biofizika. 1991; 36(4):594-8.
[4] Remizov AB, Alpatova MV, Nasibullin RS. The association of phospholipids and pyrazole. Biologicheskie Membrany. 1991; 8(4):419-22.
[5] Nasibullin RS, Remizov AB, Alparova MV, Nasyrov KM. Hydrogen bond formation between pyrazole and pyrazole derivatives and cellular membrane phospholipids in solutions. Pharmaceutical Chemistry Journal. 1991;25(12):851–4.
[6] Nasibullin RS, Latypova RG, Troitskaya VS, Vinokurov VG, Pozdeev NM. Structure, dipole moment, and quadrupole bonding constants of pyrazole. J Struct Chem. 1974;15(1):41–4.
[7] Nasibullin RS, Serebrenik MA. A change of conformation properties of cellular phospholipids effected by molecule of pyrazole. Biopolym Cell. 1997; 13(2):108-112.
[8] Nasibullin RS, Kosareva DI. Effect of pyridine on the conformational properties of phospholipids of cell membranes. Materials Conf. "Structure and dynamics of molecular. systems. "Yoshkar-Ola, 1997;3:45-8.
[9] Dawson RM. On the mechanism of action of phospholipase A. Biochem J. 1963;88:414-23.
[10] Breitmaier E, Spohn K-H. PH-abh?ngigkeit der 13C-chemischen verschiebungen sechsgliedriger stickstoff-heteroaromaten. Tetrahedron. 1973;29(8):1145–52.
[11] Dewar M. J. C. The molecular theory of organic chemistry. New York: Mc Graw-Hill, 1969.
[12] Hovorun DM. A structural isomerism of nucleotide bases: AMI calculation. Biopolym Cell. 1997; 13(2):127-34.
[13] Nasibullin RS, Sultanova VS, Zagitov GN, Zeleev MH. Study of pyrazole influence on conformative condition of phospholipids of cellular memnranes. Biofizika. 1993;38(4):684-6.
[14] Oldfield E, Chapman D. Carbon-13 pulse Fourier transform N. M. R. of lecithins. Biochem Biophys Res Commun. 1971;43(5):949-53.