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Synthesis of novel 2',3'-dideoxy-6-azacytidine derivatives – potential retroviral reproduction inhibitors
- Institute of Molecular Biology and Genetics, NAS of Ukraine
150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
This paper deals with the synthesis of the novel 2',3'-dihalo-2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxy-analogues of 6-azacytidine as potential antiviral substances. The compounds were prepared by means of the appropriate reagents – triphenylphosphonium halogen salts. The first step of the 6-azacytidine conversion results in 2,3-epoxynucleosides as against deoxygenation of uridine and thymidine, when O2, 2'-cyclonucleosides are generated.
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