Biopolym. Cell. 2001; 17(6):560-564.
Bioorganic Chemistry
Synthesis of novel 2',3'-dideoxy-6-azacytidine derivatives – potential retroviral reproduction inhibitors
1Kostina V. G., 1Alexeeva I. V., 1Palchikovskaya L. I.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


This paper deals with the synthesis of the novel 2',3'-dihalo-2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxy-analogues of 6-azacytidine as potential antiviral substances. The compounds were prepared by means of the appropriate reagents – triphenylphosphonium halogen salts. The first step of the 6-azacytidine conversion results in 2,3-epoxynucleosides as against deoxygenation of uridine and thymidine, when O2, 2'-cyclonucleosides are generated.


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