Biopolym. Cell. 2001; 17(6):522-525.
Structure and Function of Biopolymers
On the role of mitochondria in the regulation of contractile activity in smooth muscle
1Davidovskaya T. L., 1Tsimbalyuk O. V., 1Miroshnichenko M. S., 1Prylutskyy Yu. I., 2Kosterin S. A.
  1. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033
  2. Palladin Institute of Biochemistry, NAS of Ukraine
    9, Leontovycha Str., Kyiv, Ukraine, 01601


The mathematical model of the Ca -dependent control of smooth muscle contracting activity is proposed. It is based on the modern ideas relative to the molecular mechanisms of the functioning of the membrane-associated and energy-dependent Ca -transportation systems, localized in the plasmatic membrane, mitochondria and sarcoplasmic reticulum. The phases of contraction and relaxation of muscle, realized simultaneously, are numerically calculated. A role of mitochondria in the Ca -dependent control of contraction is analyzed in detail. The values of some biochemical constants, which characterize the kinetics of the calcium transport into the smooth muscle cell are are defined more precisely.


[1] Kuriyama H, Kitamura K, Itoh T, Inoue R. Physiological features of visceral smooth muscle cells, with special reference to receptors and ion channels. Physiol Rev. 1998;78(3):811-920.
[2] Zholos OV. Membrane and intracellular mechanisms of M-cholinergic activation smoothly muscular cells of the small intestine: Auth Thesis. ... Dr. biol. nauk. Kyiv, 1999. 32 p.
[3] Somlyo AP, Himpens B. Cell calcium and its regulation in smooth muscle. FASEB J. 1989;3(11):2266-76.
[4] Yamamoto H, van Breemen C. Ca2+ compartments in saponin-skinned cultured vascular smooth muscle cells. J Gen Physiol. 1986;87(3):369-89.
[5] Gurney AM, Drummond RM, Fay FS. Calcium signalling in sarcoplasmic reticulum, cytoplasm and mitochondria during activation of rabbit aorta myocytes. Cell Calcium. 2000;27(6):339-51.
[6] McGeown JG, McCarron JG, Drummond RM, Fay FS. Calcium-calmodulin-dependent mechanisms accelerate calcium decay in gastric myocytes from Bufo marinus. J Physiol. 1998;506 ( Pt 1):95-107.
[7] Drummond RM, Mix TC, Tuft RA, Walsh JV Jr, Fay FS. Mitochondrial Ca2+ homeostasis during Ca2+ influx and Ca2+ release in gastric myocytes from Bufo marinus. J Physiol. 2000;522 Pt 3:375-90.
[8] Ichas F, Jouaville LS, Sidash SS, Mazat JP, Holmuhamedov EL. Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling. FEBS Lett. 1994;348(2):211-5.
[9] Bolton TB, Prestwich SA, Zholos AV, Gordienko DV. Excitation-contraction coupling in gastrointestinal and other smooth muscles. Annu Rev Physiol. 1999;61:85-115.
[10] Kosterin SA. Transport of calcium in the smooth muscles. Kiev: Naukova Dumka. 1990; 216 p.
[11] Kosterin SA, Burdyga MV, Fomin VP, Grover AK. Control of Uterine Contractility. Eds R. E. Garfield, T. N. Tabb. Boca Raton: CRC press, 1994: 129-53.