Biopolym. Cell. 2001; 17(5):428-433.
Heparin and rat brain heparin-binding proteins take part in the process of hyperalgesia
1Ushakova G. A., 1Kornilovska I. N., 1Kobeliatsky Y. Y.
  1. Dnipropetrovsk National University Oles Gonchar
    72, Gagarin Av., Dnipropetrovs'k, Ukraine, 49050


It was shown that a hyperalgesia state resulted in the decrease of the mast cell degranulation degree and therefore diminished the amount of free heparin. In-parallel, the augmentation of heparin-binding activity of the rat brain proteins in hemispheres was detected. The morphine or ketamine application 5 min prior to operation preserves the heparin-binding activity of these proteins at the preoperative level


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