Biopolym. Cell. 2000; 16(3):212-219.
Structure and Function of Biopolymers
PDMS study of the steroid glycosides interaction with amino acids
1Pilipenko V. V., 1Aksyonov S. A., 1Kalinkevich A. N., 1Sukhodub L. F.
- Institute of Applied Physics, NAS of Ukraine
58, Petropavlivska Str., Sumy, Ukraine, 40030
Abstract
Steroid glycosides (SG) are nontoxic substances of plant origin with high physiological activity. Some SG have fungicide, antitumor, antiviral and other effect. In this work Cf-252 Plasma Desorption Mass Spectrometry has been used to investigate model mixtures of SG Bioside neotigogenine and Trioside neotigogenine extracted from Tomato seeds with amino acids. From the mass-spectra obtained it is seen that these SG have an ability to form noncovalently bound associates with some amino acids like [SG + amino acid + H]+ and [SG + amino acid + K]+.
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References
[1]
Kintia PK. Chemistry and biological activity of steroid saponins from Moldovian plants. Adv Exp Med Biol. 1996;404:309-34.
[2]
Kintia PK, Lazuryevskiy GK, Balashova NN, Balashova IT, Suruzhiu AI, Lyakh VA. Structure and biological activity of steroidal glycosides of the spirostan and furostan series. Kishinau: Shtiintsa, 1987: 240 p.
[3]
Kamernitskiy AV, Abubakiriev NK, Gorovits MB. Chemistry spirostanolov. M.: Nauka, 1986. 176 p.
[4]
Tentsova A, Lebedeva-Kosova TA. Steroidal glycosides as an active substances. Farmatsiya. 1985; 3: 81-6.
[5]
Akhov LS, Golovko EA. Biological activity of saponins. Fiziologiia i biokhimiia kul'turnykh rasteniy. 1998; 30(2):112-23.
[6]
Syrov VN, Kravets SD, Khushbaktova ZA, Nabiyev AN, Vollerner YuS, Gorovits MB. Study of steroid genins and glycosides as antiinflammatory agents. Khimiko-Farmatsevticheskii Zhurnal. 1992;5: 71-5.
[7]
Jurzysta M, Waller GR. Antifungal and Hemolytic Activity of Aerial Parts of Alfalfa (Medicago) Species in Relation to Saponin Composition. Adv Exp Med Biol. 1996;565–74.
[8]
Waller GR, West PR, Cheng CS, Ling YC, Chou CH. The occurrence of soyasaponin I in Vigna radiata L. (mungbean) sprouts as determined by fast atom bombardment, liquid secondary ion mass spectrometry, and linked scanning at constant B. E MS. MS. Bot. Bull Acad Sin. 1993; 34: 323-34.
[9]
Waller GR, Jurzysta M, Thorne RIZ. Root saponins from alfalfa (Medicago sativa L.) and their allelopathic activity on weeds and wheat. Allelopathy J. 1995; 2(1): 21-30.
[10]
Chang-Hung C, Waller GR, Cheng CS, Yang CF, Kim D. Allelochemical activity of naturally occurring compounds from mungbean (Vigna radiata L.) plants and their surrounding soil 7. Bot: Bull Acad Sin. 1995; 36: 9-18.
[11]
Shvets SA, Kintia PK, Naibi MA. Steroidal glycosides from Petunia hybrida L. seeds and their biological activity. Adv Exp Med Biol. 1996;404:251-62.
[12]
Spinu K, Vorozhbit V, Grushko T, Kintia P, Skofertsa P, Vutkaryov V, Bologa V. Antiviral activity of tomatoside from Lycopersicon esculentum Mill. Adv Exp Med Biol. 1996;404:505-9.
[13]
Fieser LF, Fieser M. Steroids, New York: Reinhold publ. corp., 1959, 114 p.
[14]
Heftman E. Biochemistry of steroidal saponins and glyco-alkoloids. Lloydia. 1967; 30: 209.
[15]
Gatsura VV, Kudrin AN. Cardiac glycosides in the heart failure complex therapy. M.: Meditsina, 1983; 204 p.
[16]
Ryff IM, Krepkova LV, Arzamastseva EV, Rudzhianska?te AF, Puchkova VA. [Pathomorphological criteria of anti-atherosclerotic effect of plant saponins in an experiment]. Biull Eksp Biol Med. 1988;106(9):365-8.
[17]
Kemertelidze EP, Pkheizde TA, Kachukashvili TI, Umikashvili RS, Turova AD, Sokolova LN. A new antisclerotic drug Tribusponin. Khimiko-Farmatsevticheskii Zhurnal. 1982; 1: 119-21.
[18]
Costello CE. Application of tandem mass spectral approaches to structural determinations of saponins. Adv Exp Med Biol. 1996;405:317-30.
[19]
Lee MK, Ling YC, Jurzysta M, Waller GR. Saponins from alfalfa, clover, and mungbeans analyzed by electrospray ionization-mass spectrometry as compared with positive and negative FAB-mass spectrometry. Adv Exp Med Biol. 1996;405:353-64.
[20]
Maillard MP, Hostettmann K. Determination of saponins in crude plant extracts by liquid chromatography—thermospray mass spectrometry. J Chromatography A. 1993;647(1):137–46.
[21]
Macfarlane RD, Hu ZH, Song S, Pittenauer E, Schmid ER, Allmaier G, Metzger JO, Tuszynski W. 252Cf-plasma desorption mass spectrometry. II--A perspective of new directions. Biol Mass Spectrom. 1994;23(3):117-30.
[22]
Sundijvist BUR. Plasma desorption mass spectrometry. Studios of mechanisms and applications. Bioorg Khim. 1991; 17(10): 1313-28.
[23]
Sukhodub LF. Soft-ionization mass spectrometry study of deoxynucleoside bioclusters and deoxynucleoside-antitumor medicinal preparation clusters. Mass Spectrometry Rev. 1995;14(4-5):235–54.
[24]
Pilipenko VV, Aksyonov SO, Kalinkevich OM, Sukhodub LF. The study of the interaction of saponins from amino acids by plasma desorption mass spectrometry. Congress UBFT: Proc. Kharkov, 1998: 60.
[25]
Kalinichenko TG, Aksyonov SA, Chivanov VD, Sukhodub LF. Biochemical analytical capabilities TOF mass spectrometer MSBH ionization fission fragments 252-Cf The Case of steroidal glycosides of plant origin. Scientific and engineering. Conf. "Engineering and physics of electronic systems and devices. Proc. Sumy, 1995: 25.
[26]
Gorchakova NA, Samarskaya TG, Samarskiy VA, Izina GG, Grischenko LI, Babak VV. Complexation of cardiac glycosides to amino acids and alkali metals. Farmakol Toksikol. 1992; 27: 106-9.
[27]
Litvinov VB. Non-receptor regulation of cell metabolism amino acids and lipids. Farmakol Toksikol. 1992; 27:82-5.
[28]
White A, Handler P, Smith EL, Hill RL, Lehman IR. Principles of Biochemistry, 6th Edition, McGraw-Hill, New York 1978
