Biopolym. Cell. 1999; 15(3):207-212.
Structure and Function of Biopolymers
Search for HIV and herpes Inhibitors among the derivatives of polyhedranee and pyridinecarboxylic acid
1Danilenko G. I., 2Rybalko S. L., 3Maximov Ju. M., 3Sharykina N. I., 2Diadiun S. T., 3Arkadiev V. G., 3Danilenko V. P., 4Nesterova N. V., 1Guzhova S. V., 3Bukhtiarova T. A., 3Ovrusky K. M., 2Zakhartsev O. Yu., 2Gritsak T. F., 2Maksimenok E. V., 1Vrichanu N. O.
  1. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094
  2. Gromashevsky L.V. Institute of Epidemiology and Infection Diseases, AMS of Ukraine
    5, Amosova Str., Kyiv, Ukraine, 03038
  3. Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
    14, Eugene Pottier Str., Kyiv, Ukraine, 03057
  4. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

It was found that an adamantane derivative (5) inhibits HIV replication as azidothymidin but has immuitostimu/ative properties. The derivatives of isonicotinic acid (2) anil norbornane (4) manifest both antiherpes and immunostimu/ative activity.

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