Search for HIV and herpes Inhibitors among the derivatives of polyhedranee and pyridinecarboxylic acid

Danilenko, G. I.; Rybalko, S. L.; Maximov, Ju. M.; Sharykina, N. I.; Diadiun, S. T.; Arkadiev, V. G.; Danilenko, V. P.; Nesterova, N. V.; Guzhova, S. V.; Bukhtiarova, T. A.; Ovrusky, K. M.; Zakhartsev, O. Yu.; Gritsak, T. F.; Maksimenok, E. V.; Vrichanu, N. O.

doi:10.7124/bc.00051A

Biopolym. Cell. 1999; 15(3):207-212.

http://dx.doi.org/10.7124/bc.00051A

Structure and Function of Biopolymers

Search for HIV and herpes Inhibitors among the derivatives of polyhedranee and pyridinecarboxylic acid

1Danilenko G. I., 2Rybalko S. L., 3Maximov Ju. M., 3Sharykina N. I., 2Diadiun S. T., 3Arkadiev V. G., 3Danilenko V. P., 4Nesterova N. V., 1Guzhova S. V., 3Bukhtiarova T. A., 3Ovrusky K. M., 2Zakhartsev O. Yu., 2Gritsak T. F., 2Maksimenok E. V., 1Vrichanu N. O.

Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
1, Murmans'ka Str., Kyiv, Ukraine, 02094
Gromashevsky L.V. Institute of Epidemiology and Infection Diseases, AMS of Ukraine
5, Amosova Str., Kyiv, Ukraine, 03038
Institute of Pharmacology and Toxicology of National Medical Academy of Science of Ukraine
14, Eugene Pottier Str., Kyiv, Ukraine, 03057
D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

It was found that an adamantane derivative (5) inhibits HIV replication as azidothymidin but has immuitostimu/ative properties. The derivatives of isonicotinic acid (2) anil norbornane (4) manifest both antiherpes and immunostimu/ative activity.

Full text: (PDF, in Ukrainian)

Abstract

References