Biopolym. Cell. 1998; 14(6):553-558.
Methods
The high scale screening of confounds of the series of isoflavonoids and 4-phenylcoumarins with the use of microorganisms
1Zhyvoloup A. M., 1Yarmoluk S. M., 1Garazd M. M., 2Garazd Y. L., 2Shylin V. V., 2Ogorodniychuk A. S., 3Khyla V. P.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680
  2. Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine
    1, Murmans'ka Str., Kyiv, Ukraine, 02094
  3. Taras Shevchenko National University of Kyiv
    64, Volodymyrska Str., Kyiv, Ukraine, 01033

Abstract

In order to investigate antimicrobial activity of more then 300 compounds of the series of isoflavonoids and 4-phenylcoumarins Salmonella typhimurium LT.2, Escherichia coli and Candida albicans were used. Two structural chemical fragments 7-(1-R1-2-R2-1-on-ethyl)-O-4-phenylcoumarin and 2-R4-3-R5-6-R2-8-R3-7-R1 O- chromone possessing antibactericidal and anticandidal effects were determined.

References

[1] Hogan JC Jr. Combinatorial chemistry in drug discovery. Nat Biotechnol. 1997;15(4):328-30.
[2] Ferguson AM. Designing Chemical Libraries for Lead Discovery. J Biomol Screen. 1996;1(2):65–73.
[3] Klein RD. Recombinant Microorganisms as Tools for High Throughput Screening for Nonantibiotic Compounds. J Biomol Screen. 1997;2(1):41–9.
[4] Kazakov A, Khilya VP, Mezheretskiy VV, Yashyken D. Natural and modified isoflavones. Rostov-na-Donu: Izd RGU, 1985:181
[5] Labinskaya AS. Microbiology with the technique of microbiological research. M.: Meditsina, 1978. 392 p.
[6] Utevskiy NL. Microbiology with the technique of microbiological tests. M.: Meditsina, 1975; 472 p.
[7] Miller JH. Experiments in molecular genetics, Cold Spring Harbor Laboratory, 1972; 466 p.
[8] Pirt CJ. Principles of microbe and cell cultivation. John Wiley & Sons 1975; 274 p.
[9] Strachunekiy LS, Kozlov AYa. Antibiotics: Clinical Pharmacology: A Guide for Physicians. Smolensk Ami Pres, 1994; 207 p.
[10] Franklin TJ, Snow GA. Biochemistry of antimicrobial action, third edition 1981
[11] Kulaga VV, Romanenko IM, Chernomordak AV. Candida and their treatment. Kiev: Zdorov'e, 1985; 125 p.
[12] Maksyutina NP, Komissarenko IB, Prokopenko AP et al. Herbal Remedies. Kiev: Zdorov'e, 1985. 280 p.