Biopolym. Cell. 1998; 14(3):223-230.
Genome and Its Regulation
Regulation of the type I interferon genes and interferon-inducible genes. 1. Organization of the promoter regulatory sequences
1Karpov A. V.
  1. D. K. Zabolotny Institute of Microbiology and Virology, NAS of Ukraine
    154, Academika Zabolotnogo Str., Kyiv, Ukraine, 03680

Abstract

A review of information concerning the regulatory motifs in the genes coding the 1 type interferons (α- and β-lFNs) and IFN-inducibie genes is presented. The structural properties of the domains realizing both positive and negative expression regulation of these genes as well as the functional peculiarity of such sequences in heterologous promoter structures have been described. Taking into account the novel data the significance of regulatory sequences conformation above and in transcriptional complexes for the effectivity of the interferon genes expression is emphasized

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