Biopolym. Cell. 1998; 14(1):5-11.
Molecular and genetic aspects of fragile X syndrome (Martin-Bell)
1Malyarchuk S. C.
  1. Institute of Molecular Biology and Genetics, NAS of Ukraine
    150, Akademika Zabolotnoho Str., Kyiv, Ukraine, 03680


Fragile X syndrome (Martin-Bell) is a common cause of mental retardation that is inherited as an X-linked dominant disorder with reduced penetrance. The incidence of fragile X syndrome is estimated to be approximately one pur 1500 males and one per 2500 females. This review represents the modern data about FMRI gene structure, dynamic mutations caused by expansion of intragenic CGG-trinucleolide repeals as well as other types of mutations at that gene.


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